Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5etm1Lft mutation
(3 available);
any
Nt5e mutation
(31 available)
|
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integument
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• mild calcification of the fibrous capsule surrounding the muzzle vibrissae is observed by one year of age
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growth/size/body
homeostasis/metabolism
craniofacial
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5etm1Lft mutation
(3 available);
any
Nt5e mutation
(31 available)
|
|
|
behavior/neurological
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• under hypoxic conditions mutants are more lethargic compared to wild-type littermates
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• under hypoxic conditions mutants are less compliant compared to wild-type littermates
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cardiovascular system
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• ischemic preconditioning fails to attenuate infarct size as in wild-type mice
• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning
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• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice
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• under hypoxic conditions increased vascular leakage is seen
• under normoxic conditions increased vascular permeability is seen in the lung and colon
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homeostasis/metabolism
homeostasis/metabolism
integument
|
• mild calcification of the fibrous capsule surrounding the muzzle vibrissae is observed by one year of age
|
growth/size/body
craniofacial