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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fosl2tm1Wag
targeted mutation 1, Erwin F Wagner
MGI:3521815
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fosl2tm1Wag/Fosl2tm1Wag involves: 129 * C57BL/6 MGI:3522177


Genotype
MGI:3522177
hm1
Allelic
Composition
Fosl2tm1Wag/Fosl2tm1Wag
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm1Wag mutation (0 available); any Fosl2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die during the first week after birth

growth/size/body
• growth retardation after P1

skeleton
• less calcified matrix was deposited in vertebrae at E16.5
• at E14.5, cells of the primordial arches of developing vertebrae appeared smaller and less hypertrophic
• impaired chondrocyte differentiation into mature hypertrophic chondrocytes
• reduced zone of hypertrophic chondrocytes in E14.5-P4 femoral and tibial growth plates but not at E13.5
• slight reduction at E15.5 and more pronounced reduction at E17.5 of extracellular matrix deposition in the epiphysis
• delayed development of vertebral columns
• initiation of endochondral ossification of the spine was delayed for 1-2 days





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory