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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hap1tm1Id
targeted mutation 1, Ioannis Dragatsis
MGI:3521576
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hap1tm1Id/Hap1tm1Id involves: 129 * C57BL/6 MGI:3521636
ht2
 		Hap1tm1Id/Hap1tm2Id involves: 129S1/Sv * C57BL/6 MGI:3521637
cn3
 		Hap1tm1Id/Hap1tm2Id
Tg(Camk2a-cre)2Szi/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:3521638
cx4
 		Hap1tm1Id/Hap1tm1Id
Htttm1Szi/Htttm1Szi 		involves: 129S/SvEv * 129S1/Sv * C57BL/6 MGI:3521639
cx5
 		Hap1tm1Id/Hap1+
Htttm1Szi/Htttm1Szi 		involves: 129S/SvEv * 129S1/Sv * C57BL/6 MGI:3521640


Genotype
MGI:3521636
hm1
Allelic
Composition		 Hap1tm1Id/Hap1tm1Id
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm1Id mutation (0 available); any Hap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:94581 )
• most mutants die by P3 with only 8% surviving to 2 weeks and most of these dying before weaning
• decreasing litter sizes can increase mutant survival allowing some mutants to survive to adulthood

behavior/neurological
absent gastric milk in neonates ( J:94581 )
• no milk is seen in mutant stomachs
abnormal suckling behavior ( J:94581 )
• mutants have a normal rooting reflex but an increased latency time for attachment to the nipple and more mutants fail to attach to the nipple

growth/size/body
postnatal growth retardation ( J:94581 )
• mutants that survive to 2 weeks show a 70% reduction in body size
• adult mutants from litters that were decreased in size show decreased growth rates for the first 3 weeks of life but growth rates after weaning are similar to wild-type mic




Genotype
MGI:3521637
ht2
Allelic
Composition		 Hap1tm1Id/Hap1tm2Id
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm1Id mutation (0 available); any Hap1 mutation (37 available)
Hap1tm2Id mutation (0 available); any Hap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:94581 )
• most mutants die by P3 with only 8% surviving to 2 weeks and most of these dying before weaning

behavior/neurological
abnormal suckling behavior ( J:94581 )
• mutants have a normal rooting reflex but an increased latency time for attachment to the nipple and more mutants fail to attach to the nipple
• no milk is seen in mutant stomachs

growth/size/body
postnatal growth retardation ( J:94581 )
• mutants that survive to 2 weeks show a 70% reduction in body size




Genotype
MGI:3521638
cn3
Allelic
Composition		 Hap1tm1Id/Hap1tm2Id
Tg(Camk2a-cre)2Szi/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm1Id mutation (0 available); any Hap1 mutation (37 available)
Hap1tm2Id mutation (0 available); any Hap1 mutation (37 available)
Tg(Camk2a-cre)2Szi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:94581 )
• postnatal lethality is no longer seen in mutants however a slight growth deficiency is seen with mutants at P21 only about 70% of the size of wild-type littermates




Genotype
MGI:3521639
cx4
Allelic
Composition		 Hap1tm1Id/Hap1tm1Id
Htttm1Szi/Htttm1Szi
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm1Id mutation (0 available); any Hap1 mutation (37 available)
Htttm1Szi mutation (0 available); any Htt mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:94581 )
• at E8.5 the embryonic portion of the conceptus is smaller than normal similar to Hdhtm1Szi single homozygotes
absent neural folds ( J:94581 )
• at E8.5 neural folds are absent similar to Hdhtm1Szi single homozygotes
absent somites ( J:94581 )
• at E8.5 somites are absent similar to Hdhtm1Szi single homozygotes

growth/size/body
decreased embryo size ( J:94581 )
• at E8.5 the embryonic portion of the conceptus is smaller than normal similar to Hdhtm1Szi single homozygotes




Genotype
MGI:3521640
cx5
Allelic
Composition		 Hap1tm1Id/Hap1+
Htttm1Szi/Htttm1Szi
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hap1tm1Id mutation (0 available); any Hap1 mutation (37 available)
Htttm1Szi mutation (0 available); any Htt mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:94581 )
• at E8.5 the embryonic portion of the conceptus is smaller than normal similar to Hdhtm1Szi single homozygotes
absent neural folds ( J:94581 )
• at E8.5 neural folds are absent similar to Hdhtm1Szi single homozygotes
absent somites ( J:94581 )
• at E8.5 somites are absent similar to Hdhtm1Szi single homozygotes

growth/size/body
decreased embryo size ( J:94581 )
• at E8.5 the embryonic portion of the conceptus is smaller than normal similar to Hdhtm1Szi single homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory