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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park7tm1Tmd
targeted mutation 1, Ted Dawson
MGI:3514165
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park7tm1Tmd/Park7tm1Tmd involves: 129S/SvEv * C57BL/6 MGI:3723643


Genotype
MGI:3723643
hm1
Allelic
Composition
Park7tm1Tmd/Park7tm1Tmd
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7tm1Tmd mutation (0 available); any Park7 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in the brains of 3 to 4 and 18 to 24 month old mice, hydrogen peroxide production is increased 2-fold and succinate-supported hydrogen peroxide production is increased relative to in wild-type mice in an age-dependent manner with older mice producing more hydrogen peroxide
• in the brains of older mice, manganese superoxidase and mitochondrial glutathione peroxidase activity are increased
• aconitase activity is reduced 60% in brain mitochondria relative to in wild-type mice

nervous system
N
• despite increased production of hydrogen peroxide in the brain, no defects in brain morphology or in the nigrostriatal pathway are detected





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory