Analysis Tools
behavior/neurological
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• no defects in motor function were seen in a fixed bar test, rotarod test, open-field test or forced swimming test, demonstrating that no significant deficiencies in motor coordination or motor ability occurred in mutant mice
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growth/size/body
muscle
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• the sarcoplasmic reticulum appeared abnormal with irregular orientation of networks and swollen, fragmented and/or vacuolated regions
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• abnormal T tubule morphology; rounded appearance and abnormal orientation
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• small muscle cell size
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• the number of triad junctions was reduced in mutant skeletal muscle
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• twitch tension was reduced in mutant skeletal muscle; mutant muscle cultured in calcium free conditions exhibited a faster decrease of twitch tension than controls
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