Phenotypes associated with this allele

• Allele Symbol: Ap3b2^tm1Bur
• Allele Name: targeted mutation 1, Margit Burmeister
• Allele ID: MGI:3513518
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap3b2^tm1Bur/Ap3b2^tm1Bur	C57BL/6-Ap3b2^tm1Bur	MGI:3522639

Genotype
MGI:3522639

hm1

• Allelic Composition: Ap3b2^tm1Bur/Ap3b2^tm1Bur
• Genetic Background: C57BL/6-Ap3b2^tm1Bur

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperactivity ( J:94942 )

• mutants are about twice as active during the first 30 minutes in an open field test

tonic-clonic seizures ( J:94942 )

• tonic-clonic seizures

nervous system

abnormal nervous system physiology ( J:94942 )

• synaptic zinc levels are reduced throughout the brain by on average about 25%, with the largest reduction (about 62% of control) in the CA1 stratum oriens

tonic-clonic seizures ( J:94942 )

• tonic-clonic seizures

integument

integument phenotype ( J:94942 )

N • coat and skin color are normal