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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zic1/Zic4tm1Kjmi
targeted mutation 1, Kathleen J Millen
MGI:3510680
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Zic1/Zic4tm1Kjmi/Zic1+ involves: 129P2/OlaHsd * C57BL/6J MGI:3511193


Genotype
MGI:3511193
ht1
Allelic
Composition
Zic1/Zic4tm1Kjmi/Zic1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1/Zic4tm1Kjmi mutation (0 available); any Zic1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severely affected heterozygotes (15% of all heterozygotes) do not survive past weaning

behavior/neurological
• severely affected heterozygotes (15% of all heterozygotes) do not develop a normal righting reflex by P10

growth/size/body
• average body weight in severely affected heterozygotes (15% of all heterozygotes) is 45% that of wild-type littermates

nervous system
• in 85% of heterozygotes mild defects are seen in the anterior folia
• in 15% of heterozygotes severe foliar defects are seen
• in mildly affected heterozygotes, the vermis is slightly smaller compared to wild-type mice
• in severely affected heterozygotes disproportionate vermis hypoplasia is seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Dandy-Walker Syndrome; DWS 220200 J:93955





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory