Mouse Genome Informatics
hm1
    Psen1tm1Lpr/Psen1tm1Lpr
involves: 129 * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• basal cholesterol levels are increase compared to wild-type controls probably as a result of differences in strain background


Mouse Genome Informatics
cx2
    Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0

either: 129/Sv or (involves: 129/Sv * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques
• marked reduction in thickness of the hippocampal pyramidal cell layer by 10 months of age
• no amyloid plaques in the CA1/2 pyramidal cell layer

homeostasis/metabolism
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:93770
Alzheimer Disease; AD 104300 J:93770


Mouse Genome Informatics
cx3
    Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0

involves: 129 * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)
• amyloid beta plaques form but no intracellular aggregates are seen
• numerous plaques form between 2 and 6 months of age and the pathology increases with age
• unlike in the frontal cortex, no neuronal loss is detected in the thalamus
• the granule cell layer is less densely packed at 12 months of age compared to 2 months of age
• the granule cell border is often frayed
• ectopic cells that are often orientated towards extracellular amyloid deposits can be detected at 2 months of age
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus
• decrease in the number of dentate gyrus granule cells at 12 months of age
• decrease in the number of dentate gyrus granule cells at 12 months of age
• massive intra- and extra-cellular amyloid beta deposits are detected in the frontal cortex at as early as 1.5 months of age, before significant plaque formation is detected
• by 6 months of age intracellular accumulations are no longer a prominent pathological feature
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls
• frontal cortex volume is reduced compared to controls at 6 and 12 months of age
• thickened and irregularly shaped neurites are seen in the medulla at 14 months of age
• axonal spheroids are detected in pons and cortical areas at 6 months of age and in the spinal cord mostly along the anterior margin of the ventral horn and less frequently in the intermediolateral and dorsal horn
• at 10 and 14 months of age axonal spheroids are detected in pons, cortex, medulla, midbrain, hippocampus, corpus callosum and striatum
• larger axonal varicosities are seen in the medulla at 14 months of age
• large axonal dilatations are localized in white matter fiber tracts in close vicinity to the ventral horn in the spinal cord
• dilated axons often display thinned or focally absent myelin sheaths
• increased deposition of myelin ovoids in the white matter
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls

homeostasis/metabolism
• significant decrease in plasma cholesterol between 2 and 6 months of age that is not seen in wild-type controls or either single transgenic mice
• basal cholesterol levels are increase compared to wild-type controls probably as a result of differences in strain background
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)

behavior/neurological
• at 10 and 14 months of age
• impaired performance in a balance beam test at 10 and 14 months of age

growth/size/body
• at 10 and 14 months of age compared to mutant mice not carrying the transgene

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:128106