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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmp19tm1Amp
targeted mutation 1, Alberto M Pendas
MGI:3505589
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmp19tm1Amp/Mmp19tm1Amp Not Specified MGI:3505708


Genotype
MGI:3505708
hm1
Allelic
Composition
Mmp19tm1Amp/Mmp19tm1Amp
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp19tm1Amp mutation (0 available); any Mmp19 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after 30 weeks on a high-fat diet, a pronounced weight gain was observed in both females and males due to an overall increase in both subcutaneous and gonadal fat pad deposits

homeostasis/metabolism
• after 30 weeks on a high-fat diet, a pronounced weight gain was observed in both females and males due to an overall increase in both subcutaneous and gonadal fat pad deposits
• intradermal injection of a single dose of the chemical carcinogen MCA resulted in fewer fibrosarcomas with a longer latency period than in wild-type

adipose tissue
• after 30 weeks on a high-fat diet, surfaces of subcutaneous, gonadal and skin adipocytes were bigger than wild-type except for the gonadal fat pad from male mutants and the number of adipocytes per surface unit was lower
• after 30 weeks on a high-fat diet, weight of subcutaneous fat pad from the posterior iliac crest deposits was higher than in wild-type
• after 30 weeks on a high-fat diet, weight of gonadal fat pad deposits was significantly higher in females but not males than in wild-type

neoplasm
• intradermal injection of a single dose of the chemical carcinogen MCA resulted in fewer fibrosarcomas with a longer latency period than in wild-type





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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory