About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddit4tm1Fein
targeted mutation 1, Elena Feinstein
MGI:3497720
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddit4tm1Fein/Ddit4tm1Fein involves: 129S5/SvEvBrd * C57BL/6 MGI:3510242


Genotype
MGI:3510242
hm1
Allelic
Composition
Ddit4tm1Fein/Ddit4tm1Fein
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit4tm1Fein mutation (0 available); any Ddit4 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• vascular cell death and neo-vascularization following exposure of pups from P7 to P12 to hyperoxic conditions are significantly reduced compared to wild-type mice
• apoptosis of the inner nuclear layer following exposure of pups from P7 to P12 to hyperoxic conditions is significantly reduced compared to wild-type mice
• in normoxic conditions no differences are detected in the retinas of mutants compared to wild-type littermates

nervous system
• in the peripheral nervous system at P10, P30 and P90

cardiovascular system
• vascular cell death and neo-vascularization following exposure of pups from P7 to P12 to hyperoxic conditions are significantly reduced compared to wild-type mice

cellular
• apoptosis of the inner nuclear layer following exposure of pups from P7 to P12 to hyperoxic conditions is significantly reduced compared to wild-type mice
• in normoxic conditions no differences are detected in the retinas of mutants compared to wild-type littermates





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/19/2020
MGI 6.15
The Jackson Laboratory