Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CSF2)2Ygy mutation
(2 available)
Tg(IL3)1Ygy mutation
(2 available)
Tg(KITLG)3Ygy mutation
(2 available)
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immune system
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• low levels of porcine chimerism are detected in the blood of recipent mice at 1 week, but all detectable chimerism in the blood is lost by 2 weeks;at 19-22 weeks after transplant, no chimerism is detected in the spleen or bone marrow
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• conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD
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immune system
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• engraftment of porcine bone marrow cells after bone marrow transplant into irradiated transgenic SCID mice is achieved and porcine hematopoesis is maintained at 7 weeks post-transplant with less efficiency than in mice also expressing the KITLG transgene
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immune system
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• at 1 week after transplant of bone marrow cells or PBMC from swine donors in irradiated transgenic SCID recipient mice, the percentage of porcine cells in the WBC in medronate-liposome treated (for depletion of macrophages) recipients is 10x greater than in PBS treated controls
(J:94302)
• chimerism in medronate-liposome treated mice at 8 weeks post-transplant is 60% in the marrow compared to less than 30% in PBS treated controls
(J:94302)
• engraftment of porcine bone marrow cells after bone marrow transplant into irradiated transgenic SCID mice is achieved and porcine hematopoesis is maintained at 7 weeks post-transplant compared to non transgenic littermates which lose porcine chimerism completely
(J:106416)
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immune system
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• blood of NOD-SCID mouse recipients remains chimeric for porcine hematopoietic cells throughout the length of the experiment (6 weeks):
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• conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD
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Analysis Tools