Analysis Tools
nervous system
| N |
• no amyloid plaque deposition is seen in the cerebral cortex even at 18 months of age
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Allele Symbol Allele Name Allele ID |
Tg(PDGFB-APP)5Lms transgene insertion 5, Lennart Mucke MGI:3057135 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no amyloid plaque deposition is seen in the cerebral cortex even at 18 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no amyloid plaques are detected by immunohistochemistry up to the age of 24 months
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• significantly elevated beta amyloid
• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet
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• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals
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• significantly elevated beta amyloid
• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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