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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Alcamtm1Jawe
targeted mutation 1, Joshua A Weiner
MGI:3056579
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Alcamtm1Jawe/Alcamtm1Jawe involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3057116


Genotype
MGI:3057116
hm1
Allelic
Composition
Alcamtm1Jawe/Alcamtm1Jawe
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alcamtm1Jawe mutation (2 available); any Alcam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• in 75% of mutant eyes retinal dysplasia is seen with finger like projections of photoreceptor cells protruding into the outer nuclear layer and/or invagination of the retina without disrupting the cell layers
• dysplasia can be detected on P1
• photoreceptor outer segments appear elongated and disorganized
• axons are loosely bundled and occasionally have aberrant trajectories however all exit the optic disc normally

nervous system
• motor neurons are loosely bundled with some axons exiting the bundles at a right angle to the adjacent nerve and ending blindly or forming bridges to neighboring bundles
• photoreceptor outer segments appear elongated and disorganized





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory