Mouse Genome Informatics
hm1
    Foxf2W174R/Foxf2W174R
involves: BALB/c * C3H/HeH
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Foxf2W174R/Foxf2W174R pups are smaller at 3 days after birth and consume less milk at birth

mortality/aging
• mice die within 14 days of birth

vision/eye
• formation of the ciliary body is absent in the E18.5 eye
• at E18.5, mice fail to exhibit evagination of tissue from the anterior optic cup unlike in wild-type mice

growth/size/body
• mice fail to thrive after birth

craniofacial
N
• mice exhibit normal primary and secondary palate (J:178103)

Mouse Models of Human Disease
OMIM IDRef(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:178103


Mouse Genome Informatics
ht2
    Foxf2W174R/Foxf2+
involves: BALB/c * C3H/HeH
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Iris abnormalities in Foxf2W174R/Foxf2+ mice

vision/eye
• one mouse exhibits hypoplastic ciliary muscle compared with wild-type mice
• mice exhibit extraneous amorphous tissue between the retina and the lens unlike in wild-type mice
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina
• 6 of 10 mice exhibit reduced angle between cornea and iris compared with wild-type mice
• smaller in 7 of 10 mice and absent in 2 of 10 mice
• hypoplastic ciliary body or ciliary body process
• the iris stroma sows irregular thinning of the tissue and loss of structural organization at P45
• iridocorneal adhesion is present
• in two mice at 6 months of age
• disrupted in 2 of 18 mice due to swelling of the optic nerve

nervous system
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina

homeostasis/metabolism
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina