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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxf2W174R
Trp174Arg
MGI:3056482
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxf2W174R/Foxf2W174R involves: BALB/c * C3H/HeH MGI:3717735
ht2
Foxf2W174R/Foxf2+ involves: BALB/c * C3H/HeH MGI:5297593


Genotype
MGI:3717735
hm1
Allelic
Composition
Foxf2W174R/Foxf2W174R
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf2W174R mutation (0 available); any Foxf2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Foxf2W174R/Foxf2W174R pups are smaller at 3 days after birth and consume less milk at birth

mortality/aging
• mice die within 14 days of birth

vision/eye
• formation of the ciliary body is absent in the E18.5 eye
• at E18.5, mice fail to exhibit evagination of tissue from the anterior optic cup unlike in wild-type mice

growth/size/body
• mice fail to thrive after birth

craniofacial
N
• mice exhibit normal primary and secondary palate

Mouse Models of Human Disease
OMIM ID Ref(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:178103




Genotype
MGI:5297593
ht2
Allelic
Composition
Foxf2W174R/Foxf2+
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf2W174R mutation (0 available); any Foxf2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Iris abnormalities in Foxf2W174R/Foxf2+ mice

vision/eye
• mice exhibit extraneous amorphous tissue between the retina and the lens unlike in wild-type mice
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina
• 6 of 10 mice exhibit reduced angle between cornea and iris compared with wild-type mice
• smaller in 7 of 10 mice
• absent in 2 of 10 mice
• one mouse exhibits hypoplastic ciliary muscle compared with wild-type mice
• hypoplastic ciliary body or ciliary body process
• hypoplastic ciliary body or ciliary body process
• the iris stroma sows irregular thinning of the tissue and loss of structural organization at P45
• iridocorneal adhesion is present
• in two mice at 6 months of age
• disrupted in 2 of 18 mice due to swelling of the optic nerve

nervous system
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina

homeostasis/metabolism
• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory