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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brca2tm1Mhun
targeted mutation 1, MC Hung
MGI:3055613
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Brca2tm1Mhun/Brca2tm1Mhun involves: 129S7/SvEvBrd * C57BL/6J MGI:3055717
ht2
Brca2tm1Mhun/Brca2+ involves: 129S7/SvEvBrd * C57BL/6J MGI:3055719


Genotype
MGI:3055717
hm1
Allelic
Composition
Brca2tm1Mhun/Brca2tm1Mhun
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Mhun mutation (0 available); any Brca2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes died between E8.5 and E9.5




Genotype
MGI:3055719
ht2
Allelic
Composition
Brca2tm1Mhun/Brca2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Mhun mutation (0 available); any Brca2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• remain tumor free for over a year
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

cellular
• mammary tumor cell lines grew significantly faster after the third day in culture
• very sensitive to DMBA induced apoptosis

homeostasis/metabolism
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:89083





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory