Mouse Genome Informatics
hm1
     Brca2tm1Mhun/Brca2tm1Mhun
involves: 129S7/SvEvBrd * C57BL/6J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
complete embryonic lethality during organogenesis ( J:89083 )
• homozygotes died between E8.5 and E9.5


Mouse Genome Informatics
ht2
     Brca2tm1Mhun/Brca2+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
decreased tumor incidence ( J:89083 )
• remain tumor free for over a year
decreased incidence of chemically-induced tumors ( J:89083 )
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

cellular
abnormal cell physiology ( J:89083 )
• mammary tumor cell lines grew significantly faster after the third day in culture
increased apoptosis ( J:89083 )
• very sensitive to DMBA induced apoptosis

homeostasis/metabolism
decreased incidence of chemically-induced tumors ( J:89083 )
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

Mouse Models of Human Disease
 OMIM IDRef(s)
Breast Cancer 114480 J:89083