All Phenotypes Brca2<tm1Mhun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca2^tm1Mhun
targeted mutation 1, MC Hung
MGI:3055613

Summary

2 genotypes

Allelic Composition	Brca2^tm1Mhun/Brca2^tm1Mhun
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Mhun mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• homozygotes died between E8.5 and E9.5

Allelic Composition	Brca2^tm1Mhun/Brca2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Mhun mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:89083 )

• remain tumor free for over a year

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

cellular

abnormal cell physiology ( J:89083 )

• mammary tumor cell lines grew significantly faster after the third day in culture

increased apoptosis ( J:89083 )

• very sensitive to DMBA induced apoptosis

homeostasis/metabolism

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:89083

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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