Mouse Genome Informatics
hm1
    Brca2tm1Mhun/Brca2tm1Mhun
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• homozygotes died between E8.5 and E9.5


Mouse Genome Informatics
ht2
    Brca2tm1Mhun/Brca2+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• remain tumor free for over a year
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

cellular
• mammary tumor cell lines grew significantly faster after the third day in culture
• very sensitive to DMBA induced apoptosis

homeostasis/metabolism
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:89083