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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Crh)227.1Pbl
transgene insertion 227.1, Wylie W Vale
MGI:3055440
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Crh)227.1Pbl/0 C57BL/6 MGI:3580003


Genotype
MGI:3580003
tg1
Allelic
Composition
Tg(Crh)227.1Pbl/0
Genetic
Background
C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Crh)227.1Pbl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transgenic mice exhibit increased adrenal weights
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice exhibit elevated ACTH release

homeostasis/metabolism
• notably, addition of zinc in the drinking water does not further increase the corticosterone levels in founder mice
• transgenic mice show up to a 10-fold increase in corticosterone levels relative to control non-transgenic littermates; the degree of endocrine dysfunction varies widely among founders
• transgenic mice show a 5-fold elevation in serum levels of ACTH

growth/size/body
• transgenic mice exhibit truncal obesity with large adipose deposits
• transgenic mice display decreased linear growth relative to non-transgenic littermates

muscle

reproductive system
• transgenic females show decreased fertility probably due to increased corticosterone levels or CRF levels in the brain

hematopoietic system
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice show a 3-fold reduction in spleen weight

immune system
• transgenic mice show a ~2-fold reduction in thymus weight
• transgenic mice show a 3-fold reduction in spleen weight

nervous system
• transgenic mice exhibit elevated ACTH release

integument
• transgenic mice display bilateral symmetric hair loss
• transgenic mice show abnormally transparent skin

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:92996





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory