Mouse Genome Informatics
hm1
    Dysftm1Meho/Dysftm1Meho
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• hind-limb clasping develops after 8 months of age
• inability to spread legs when suspended by their tails after 8 months of age

muscle
• perivascular infiltrates and inflammation seen by 8 months of age
• fibers with scattered degenerating and regenerating fibers by 2 months of age
• abnormalities primarily in proximal muscles at early ages
• hypertrophic fibers, fiber splitting and fat replacement are seen at 5 months of age
• nuclei are centrally placed
• by 5 months of age, increased numbers of necrotic and regenerating fibers are present
• endomysial fibrosis at 8 months of age