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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PF4MER)6Kra
transgene insertion 6, Katya Ravid
MGI:3054406
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(PF4MER)6Kra/? FVB/N-Tg(PF4MER)6Kra MGI:3798816


Genotype
MGI:3798816
tg1
Allelic
Composition
Tg(PF4MER)6Kra/?
Genetic
Background
FVB/N-Tg(PF4MER)6Kra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PF4MER)6Kra mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleens of pregnant transgenic mice are on average 24% bigger than in pregnant non-transgenic mice
• spleens of non-pregnant female mice are slightly larger than in controls

immune system
• spleens of pregnant transgenic mice are on average 24% bigger than in pregnant non-transgenic mice
• spleens of non-pregnant female mice are slightly larger than in controls

hematopoietic system
• spleens of pregnant transgenic mice are on average 24% bigger than in pregnant non-transgenic mice
• spleens of non-pregnant female mice are slightly larger than in controls
• megakaryocytes from female mice are smaller
• megakaryocytes of the same ploidy state (16N) are about 10% smaller in female transgenic mice compared to female wild-type mice
• megakaryocytes from bone marrow have higher rates of apoptosis in female transgenic mice compared to non-transgenic mice
• female transgenic mice have a significant decrease in the fraction of high ploidy (>32N) megakarocytes and an increased frequency of low ploidy megakarocytes (<8N)
• these differences in ploidy number are greater in pregnant transgenic mice when compared to pregnant non-transgenic mice
• an increased number of megakaryocytes are found in the spleen and bone marrow of female mice
• the number of megakaryocytes found in a female sternum bone marrow compartment is 65 compared to 30-35 in transgenic male mice or non-transgenic female mice
• pregnant female mice have an average of 76 megakarocytes per bone marrow compartment compared to 43 for pregnant non-transgenic females
• male mice treated with estrogen for two weeks increase the mean number of megakaryocytes to 61 per bone marrow compartment compared to 39 in estrogen-treated male wild-type mice

cellular
• megakaryocytes from bone marrow have higher rates of apoptosis in female transgenic mice compared to non-transgenic mice
• female transgenic mice have a significant decrease in the fraction of high ploidy (>32N) megakarocytes and an increased frequency of low ploidy megakarocytes (<8N)
• these differences in ploidy number are greater in pregnant transgenic mice when compared to pregnant non-transgenic mice





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory