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Allele Symbol Allele Name Allele ID |
Nr5a2tm1Auw targeted mutation 1, Johan Auwerx MGI:3053912 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following dextran sodium sulfate treatment crypts are lost
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• the colon weight-to-length ratio following dextran sodium sulfate treatment is increased indicating a decrease in the ability of the epithelium to regenerate
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• following treatment with 2,4,6-trinitrobezene sulfonic acid, a greater degree of colitis-associated necrosis occurs than in wild-type mice
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• 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice as evidenced by increased edema and vascular response
• inflammation caused by TNBS is accompanied by an increase in necrotic regions and a higher level of neutrophil infiltration
• dextran sodium sulfate induces more severe colitis than in wild-type mice
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• following treatment with 2,4,6-trinitrobezene sulfonic acid, colitis-associated edema is more severe than in wild-type mice
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• 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice as evidenced by increased edema and vascular response
• inflammation caused by TNBS is accompanied by an increase in necrotic regions and a higher level of neutrophil infiltration
• dextran sodium sulfate induces more severe colitis than in wild-type mice
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• following dextran sodium sulfate treatment crypts are lost
|
|
• following treatment with 2,4,6-trinitrobezene sulfonic acid, a greater degree of colitis-associated necrosis occurs than in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• crypt length is significantly shorter in mutants
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• crypt length is significantly shorter in mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lower plasma testosterone concentration
• however, plasma concentrations of luteinizing hormone are similar to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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