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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ANX6)2Agh
transgene insertion 2, Ann-Marie Gunteski-Hamblin
MGI:3053801
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ANX6)2Agh/Tg(ANX6)2Agh FVB/N-Tg(ANX6)2Agh MGI:3800652
tg2
Tg(ANX6)2Agh/0 FVB/N-Tg(ANX6)2Agh MGI:3800653


Genotype
MGI:3800652
tg1
Allelic
Composition
Tg(ANX6)2Agh/Tg(ANX6)2Agh
Genetic
Background
FVB/N-Tg(ANX6)2Agh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ANX6)2Agh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to weaning

cardiovascular system
• mice exhibit severe heart pathology and die prior to weaning




Genotype
MGI:3800653
tg2
Allelic
Composition
Tg(ANX6)2Agh/0
Genetic
Background
FVB/N-Tg(ANX6)2Agh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ANX6)2Agh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

cellular

cardiovascular system
• myocytes in the pulmonary vein muscular wall are replaced with fibrous tissue
• mice exhibit dilation of the atria with large thrombi that partially occludes the lumen
• mice exhibit mild heart lesions with multifocally extensive and diffuse fibrosis in the ventricles and atria that worsens with age
• mice exhibit occasional mineralization associated with fibrosis
• the myocardium and endocardium of the ventricles are most affected by fibrosis
• mice exhibit an increase in chamber turbulence or pooling in the heart
• cardiomyocytes exhibit decreased percent shortening, rate of contraction and rate of relaxation compared to wild-type mice
• cardiomyocytes exhibit a 40% lower basal level of free calcium ions and after stimulation a lower calcium ion peak compared to in wild-type mice
• however, depression of base levels of intracellular calcium ions is normal following stimulation
• heart function deteriorates with age
• mice exhibit myocyte necrosis, mild inflammation and occasional mineralization associated with fibrosis

hematopoietic system
• in some mice

immune system
• mice exhibit myocyte necrosis, mild inflammation and occasional mineralization associated with fibrosis
• in some mice

muscle
• cardiomyocytes exhibit decreased percent shortening, rate of contraction and rate of relaxation compared to wild-type mice
• heart function deteriorates with age

endocrine/exocrine glands
• in some mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory