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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(BCL2)36Wehi
transgene insertion 36, Walter and Eliza Hall Institute of Medical Research
MGI:3052954
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3834731
cx2
Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0
involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi MGI:3796509
tg3
Tg(BCL2)36Wehi/0 involves: C57BL/6JWehi * SJL/JWehi MGI:3697911
tg4
Tg(BCL2)36Wehi/? B6.Cg-Tg(BCL2)36Wehi/J MGI:3851985


Genotype
MGI:3834731
cn1
Allelic
Composition
Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (86 available)
Tg(BCL2)36Wehi mutation (3 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

immune system
N
• thymus cellularity restored




Genotype
MGI:3796509
cx2
Allelic
Composition
Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (14 available)
Tg(BCL2)36Wehi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

hematopoietic system
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene




Genotype
MGI:3697911
tg3
Allelic
Composition
Tg(BCL2)36Wehi/0
Genetic
Background
involves: C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• a few mice develop fatal clonal T cell tumors

hematopoietic system
• mutants show an excess of B lymphocytes
• mutants have an excess of T lymphocytes
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
• mice display increased serum immunoglobulin concentrations
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes

immune system
• mutants show an excess of B lymphocytes
• mutants have an excess of T lymphocytes
• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
• mice display increased serum immunoglobulin concentrations
• transgenic T cells show prolonged in vitro survival in culture compared to wild-type T lymphocytes
• some transgenic mice develop a systemic autoimmune-like disease

neoplasm
• a few mice develop fatal clonal T cell tumors




Genotype
MGI:3851985
tg4
Allelic
Composition
Tg(BCL2)36Wehi/?
Genetic
Background
B6.Cg-Tg(BCL2)36Wehi/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)36Wehi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

immune system
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls

cellular
• IL-21 fails to induce apoptosis in LPS-activated B cells as it does in wild-type mice
• anti-CD40 B cell proliferation is increased 3- to 5- fold in the presence of IL-21, which does not occur in wild-type controls





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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory