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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(BCL2)25Wehi
transgene insertion 25, Walter and Eliza Hall Institute of Medical Research
MGI:3052945
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0 		involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5805810
cx2
 		Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0 		involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5441334
tg3
 		Tg(BCL2)25Wehi/0 involves: C57BL/6JWehi * SJL/JWehi MGI:3697916


Genotype
MGI:5805810
cn1
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (61 available)
Tg(BCL2)25Wehi mutation (1 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

endocrine/exocrine glands
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes

hematopoietic system
decreased thymocyte number ( J:236298 )
• CD4+ single positive thymocytes




Genotype
MGI:5441334
cx2
Allelic
Composition		 Tg(BCL2)25Wehi/0
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131912 )
• median survival is 337 days

neoplasm
increased plasmacytoma incidence ( J:131912 )
• aggressive extramedullary monoclonal plasmacytoma with infiltration of spleen and lymph nodes




Genotype
MGI:3697916
tg3
Allelic
Composition		 Tg(BCL2)25Wehi/0
Genetic
Background		 involves: C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)25Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
abnormal plasma cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
increased T cell number ( J:93111 )
• mutants have a 2-fold excess of T lymphocytes in peripheral lymphoid organs
abnormal T cell physiology ( J:93111 )
• transgenic T cells from thymus or periphery show prolonged in vitro survival in culture compared to wild-type T lymphocytes

immune system
abnormal B cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
abnormal plasma cell differentiation ( J:131912 )
• benign polyclonal B cell and plasma cell expansion without spikes in monoclonal antibodies (M-spikes)
increased T cell number ( J:93111 )
• mutants have a 2-fold excess of T lymphocytes in peripheral lymphoid organs
abnormal T cell physiology ( J:93111 )
• transgenic T cells from thymus or periphery show prolonged in vitro survival in culture compared to wild-type T lymphocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory