Phenotypes associated with this allele
Allelic Composition |
Prnptm1Tuzi/Prnp+
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Genetic Background |
involves: 129P2/OlaHsd |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
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immune system
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• an increased incubation time for TSE strain ME7 compared to wild-type mice is seen, however this incubation time is longer than in heterozygous Prnptm2Edin mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
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immune system
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• no signs of TSE disease are seen 410 days postinfection an increased incubation time compared to wild-type mice or mutants with cre recombination
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
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immune system
N |
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation
(0 available);
any
Prnp mutation
(150 available)
Prnptm2Edin mutation
(7 available);
any
Prnp mutation
(150 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
|
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immune system
|
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice
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