Phenotypes associated with this allele

• Allele Symbol: Aadat^tm1Tag
• Allele Name: targeted mutation 1, Danilo A Tagle
• Allele ID: MGI:3052711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aadat^tm1Tag/Aadat^tm1Tag	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * Black Swiss)	MGI:3053435

Genotype
MGI:3053435

hm1

• Allelic Composition: Aadat^tm1Tag/Aadat^tm1Tag
• Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal righting response ( J:92240 )

• mutant pups develop the ability to land in a prone position when dropped sooner than wild-type pups

impaired balance ( J:92240 )

• at P21 mutant pups display a transient impairment in balance compared to wild-type mice that is not seen at 2 or 6 months of age

hyperactivity ( J:92240 )

• mutant pups display a transient increase in activity in the open field from P17 to P26

• mutant pups acquire the ability to cross an open field earlier than wild-type pups

vision/eye

early eyelid opening ( J:92240 )

• mutant eyes open about 1 day earlier compared to wild-type mice

nervous system

abnormal neuron morphology ( J:92240 )

• mutant cortical and striatal neurons display a transient increase in spine densities at P21 but not at 2 months of age