All Phenotypes Tg(Neurog3-cre)C1Able MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Neurog3-cre)C1Able
transgene insertion C1, Andrew B Leiter
MGI:3052639

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Neurog3-cre)C1Able/0 Tg(RNU6-EGFP,-RNAi:Dpp7)#Bhub/0	involves: 129 * C57BL/6 * CD-1	MGI:4438946
cn2	Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺ Tg(Neurog3-cre)C1Able/0	involves: 129S4/SvJaeSor	MGI:5460862
cn3	Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Neurog3-cre)C1Able/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4413462
cn4	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501187
cn5	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501186
cn6	Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Neurog3-cre)C1Able/0	involves: BALB/c * C57BL/6	MGI:5501184

Allelic Composition	Tg(Neurog3-cre)C1Able/0 Tg(RNU6-EGFP,-RNAi:Dpp7)#Bhub/0
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Neurog3-cre)C1Able mutation (2 available)
Tg(RNU6-EGFP,-RNAi:Dpp7)#Bhub mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:158215 )

• whether fed a low-fat or high-fat diet, serum glucose levels are higher than in wild-type mice especially in male mice

hyperglycemia ( J:158215 )

• as early as 4 months of age whether fed a low-fat or high-fat diet

increased circulating insulin level ( J:158215 )

• baseline and after glucose challenge whether fed a low-fat or high-fat diet

• as early as 4 months of age whether fed a low-fat or high-fat diet

impaired glucose tolerance ( J:158215 )

• whether fed a low-fat or high-fat diet

insulin resistance ( J:158215 )

• as early as 4 months of age whether fed a low-fat or high-fat diet

adipose tissue

increased epididymal fat pad weight ( J:158215 )

• at 7 months when fed a low-fat diet

increased abdominal fat pad weight ( J:158215 )

• when fed a high fat diet, 7 month old mice exhibit increased adiposity due to an increase in intraabdominal fat depots compared with similarly treated wild-type mice

increased percent body fat/body weight ( J:158215 )

• when fed a high fat diet due to an increase in intraabdominal fat depots at 7 months of age

liver/biliary system

increased liver weight ( J:158215 )

• at 4 and 7 months in mice fed a high-fat diet

hepatic steatosis ( J:158215 )

• mild when fed a low-fat diet

• at 7 months in mice fed a high-fat diet

behavior/neurological

abnormal eating behavior ( J:158215 )

• whether fed a low-fat or high-fat diet at 4 and 7 months of age

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:158215 )

N	• despite abnormal glucose homeostasis, pancreas morphology is normal whether mice are fed a low-fat or high-fat diet

growth/size/body

increased liver weight ( J:158215 )

• at 4 and 7 months in mice fed a high-fat diet

Allelic Composition	Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺ Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Notch1)Dam} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:190530 )

• pups lose weight, become hyperglycemic, and die by postnatal day 3 (P3)

growth/size/body

decreased body weight ( J:190530 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:190530 )

N	• endocrine differentiation is not completely abrogated, as some chromogranin A stained cells expressing EGFP are detected; some endocrine cells express PPY, with a few expressing glucagon or coexpressing PYY, but no insulin-, somatostatin-, or PP-expressing cells are observed

abnormal pancreatic duct morphology ( J:190530 )

• in contrast to normal pancreata where Neurog3-positive cells generate individual or pairs of duct cells, most EGFP-labeled cells are duct cells with Notch activation in 2-day old mice; no cells expressing both duct and endocrine markers are detected

• total numbers of duct cells are comparable to controls, but with Notch-activation, the fraction fated to duct lineage is substantially increased relative to cells fated to endocrine lineage

absent pancreatic islets ( J:190530 )

abnormal pancreas development ( J:190530 )

• islets fail to develop

digestive/alimentary system

abnormal pancreatic duct morphology ( J:190530 )

• total numbers of duct cells are comparable to controls, but with Notch-activation, the fraction fated to duct lineage is substantially increased relative to cells fated to endocrine lineage

homeostasis/metabolism

hyperglycemia ( J:190530 )

Allelic Composition	Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Onecut1^tm1.1Mga mutation (1 available); any Onecut1 mutation (12 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:155058 )

N	• mice exhibit normal beta cell differentiation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155058 )

N	• mice exhibit normal glucose homeostasis

Allelic Composition	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Pdx1^tm1Cvw mutation (1 available); any Pdx1 mutation (35 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:195153 )

• mice exhibit an increase in the glucagon to insulin cell ratio as in Pdx1^tm1Cvw heterozygotes

increased pancreatic alpha cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

decreased pancreatic beta cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:195153 )

• mice die within the first few days after birth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N	• mice do not exhibit endocrine-to-acinar fate conversion • beta cells exhibit normal cell proliferation and apoptosis

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

increased pancreatic alpha cell number ( J:195153 )

decreased pancreatic beta cell number ( J:195153 )

• due to reduced differentiation without an effect on proliferation and apoptosis

increased pancreatic delta cell number ( J:195153 )

increased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

hyperglycemia ( J:195153 )

dehydration ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

Allelic Composition	Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan mutation (0 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N	• islet cell mass and proliferation are normal

decreased pancreatic alpha cell number ( J:195153 )

increased pancreatic beta cell number ( J:195153 )

• at the expense of other islet cell types

decreased pancreatic delta cell number ( J:195153 )

decreased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195153 )

N	• mice exhibit normal glucose tolerance

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