Mouse Genome Informatics
hm1
    Slc29a1tm1Msg/Slc29a1tm1Msg
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• voluntarily consume more ethanol compared to wild-type littermates
• increase in consumption is not related to a change in taste preference as no difference in preference for saccharin or quinine is seen
• administration of an A1 receptor agonist reduces alcohol consumption and preference in mutant but not wild-type mice
• the severity of ethanol-induced motor incoordination and loss of righting reflex is reduced compared to wild-type controls
• however, blood ethanol concentrations do not differ from wild-type

nervous system
• incubation of brain slices with an A1 receptor antagonist (1,3-dipropyl-8-cyclopentylxanthine) fails to increase evoked EPSC amplitude unlike in wild-type littermate brain slices
• the frequency of spontaneous EPSCs in the striatum is increased 2.5-fold compared to wild-type littermates
• the increase in frequncy is associated with a slight but significant increase in amplitude

growth/size/body

Mouse Models of Human Disease
OMIM IDRef(s)
Alcohol Dependence 103780 J:92100