Mouse Genome Informatics
involves: 129X1/SvJ * C57BL/6J
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• voluntarily consume more ethanol compared to wild-type littermates
• increase in consumption is not related to a change in taste preference as no difference in preference for saccharin or quinine is seen
• administration of an A1 receptor agonist reduces alcohol consumption and preference in mutant but not wild-type mice
• however, blood ethanol concentrations do not differ from wild-type
• the severity of ethanol-induced motor incoordination and loss of righting reflex is reduced compared to wild-type controls

nervous system
• incubation of brain slices with an A1 receptor antagonist (1,3-dipropyl-8-cyclopentylxanthine) fails to increase evoked EPSC amplitude unlike in wild-type littermate brain slices
• the frequency of spontaneous EPSCs in the striatum is increased 2.5-fold compared to wild-type littermates
• the increase in frequncy is associated with a slight but significant increase in amplitude


Mouse Models of Human Disease
Alcohol Dependence 103780 J:92100