Phenotypes associated with this allele

• Allele Symbol: Slc17a7^tm1Bros
• Allele Name: targeted mutation 1, Nils Brose
• Allele ID: MGI:3051945
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc17a7^tm1Bros/Slc17a7^tm1Bros	involves: 129P2/OlaHsd	MGI:3718199
ht2	Slc17a7^tm1Bros/Slc17a7^+	involves: 129 * C57BL/6N	MGI:3718198

Genotype
MGI:3718199

hm1

• Allelic Composition: Slc17a7^tm1Bros/Slc17a7^tm1Bros
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:89958 )

• mice die between P18 and P21

nervous system

abnormal excitatory postsynaptic currents ( J:89958 )

• 12% of neurons have no excitatory postsynaptic current (EPSC)

• only small EPSCs are produced (0.0-0.5nA compared to greater than 0.9nA in wild-type mice)

abnormal miniature excitatory postsynaptic currents ( J:89958 )

• 26% of neurons show no miniature excitatory postsynaptic currents (mEPSCs)

• mEPSCs produced have lower release frequency and a shift towards smaller amplitude size

behavior/neurological

unresponsive to tactile stimuli ( J:89958 )

• mice become unresponsive towards the end of week 3

hunched posture ( J:89958 )

• at 3 weeks

growth/size/body

decreased body weight ( J:89958 )

• at the beginning of week 3 mice fail to thrive

postnatal growth retardation ( J:89958 )

• beginning at 3 weeks

Genotype
MGI:3718198

ht2

• Allelic Composition: Slc17a7^tm1Bros/Slc17a7⁺
• Genetic Background: involves: 129 * C57BL/6N

behavior/neurological

abnormal long-term object recognition memory ( J:118618 )

• 24 hours following the sample phase, mice do not discriminate the novel object whereas wild-type mice do

behavioral despair ( J:118618 )

• in a forced-swimming test, mice spend more time immobile compared to wild-type mice

increased anxiety-related response ( J:118618 )

• mice are more anxious in a light-dark exploration test in that mice spend less time in the white area and crossed fewer lines compared to wild-type mice

nervous system

abnormal nervous system physiology ( J:118618 )

• GABA levels in the frontal cortex and dorsal hippocampus are reduced