Phenotypes associated with this allele

• Allele Symbol: Cacna2d2^du-3J
• Allele Name: ducky 3 Jackson
• Allele ID: MGI:3051588
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna2d2^du-3J/Cacna2d2^du-3J	involves: BALB/cByJ * C57BL/6J	MGI:3051591

Genotype
MGI:3051591

hm1

• Allelic Composition: Cacna2d2^du-3J/Cacna2d2^du-3J
• Genetic Background: involves: BALB/cByJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82238 )

• with special care and feeding, homozygotes may survive until older than two months; otherwise, some die as young as 4 weeks of age

behavior/neurological

tremors ( J:82238 )

• body tremor is apparent by approximately 12 days

abnormal motor coordination/balance ( J:82238 )

• from about 5 weeks of age, mutant mice keep their hindlimbs splayed

myoclonus ( J:82238 )

• from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side

growth/size/body

decreased body size ( J:82238 )

• obvious by approximately 12 days; both body and internal organs of a 57 day-old homozygous mouse were found on pathological examination to be small and immature

muscle

myoclonus ( J:82238 )

• from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side

reproductive system

reproductive system phenotype ( J:82238 )

N • homozygous females may be able to "breed" only via transplantation of their ovaries to other hosts, however males are fertile

nervous system

myoclonus ( J:82238 )

• from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side