Phenotypes associated with this allele
Allelic Composition |
Pax7tm2Pgr/Pax7tm2Pgr
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Genetic Background |
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm2Pgr mutation
(2 available);
any
Pax7 mutation
(39 available)
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muscle
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• satellite cells are present but reduced in number
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• regeneration after a freeze-crush injury is severely impaired with areas of proper regeneration mixed with areas containing disarranged myotubes and necrotic material
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Allelic Composition |
Pax7tm2Pgr/Pax7tm2Pgr
|
|
Genetic Background |
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S2/SvPas) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm2Pgr mutation
(2 available);
any
Pax7 mutation
(39 available)
|
|
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mortality/aging
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• about 97% of homozygotes die within 3 weeks of birth
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craniofacial
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• the maxilla is shortened in the anterior-posterior direction
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• the inferior lateral portion of the nasal capsule is absent at E14.5 and in neonates
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respiratory system
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• the inferior lateral portion of the nasal capsule is absent at E14.5 and in neonates
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endocrine/exocrine glands
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• the tubules of serous glands associated with the middle meatus and nasal septum are reduced in number
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growth/size/body
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• the inferior lateral portion of the nasal capsule is absent at E14.5 and in neonates
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• growth retardation can be seen within a few days of birth
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digestive/alimentary system
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• homozygotes that survive to adulthood are unhealthy and have dilations in the small intestine and appendix
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skeleton
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• the maxilla is shortened in the anterior-posterior direction
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• the inferior lateral portion of the nasal capsule is absent at E14.5 and in neonates
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mortality/aging
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• double homozygotes die at mid-gestation
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muscle
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• at E11.5 there is a significant decrease in the differentiated muscle cells and by E13.5 only a few muscle fibers are present
• increased apoptosis is seen at E11.5 unlike in Pax3 single homozygotes
• progenitor cells at later embryonic and fetal stages are not specified as skeletal muscle
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