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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TTR-V30M)15Imeg
transgene insertion 15, Institute of Molecular Embryology and Genetics
MGI:3047080
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hsf1tm1Ijb/Hsf1tm1Ijb
Tg(TTR-V30M)15Imeg/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6 MGI:4429562
tg2
Tg(TTR-V30M)15Imeg/0 Not Specified MGI:3613376


Genotype
MGI:4429562
cx1
Allelic
Composition
Hsf1tm1Ijb/Hsf1tm1Ijb
Tg(TTR-V30M)15Imeg/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Ijb mutation (1 available); any Hsf1 mutation (7 available)
Tg(TTR-V30M)15Imeg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• as in human patients with familial amyloidotic polyneuropathy, no transthyretin deposition is observed in the brain and spinal cord
• after 24 months, mice exhibit a decrease in the number of unmyelinated fibers and myelinated fibers in sciatic nerves with transthyretin depositions unlike in wild-type mice
• at 3 months, some mice exhibit transthyretin depositions in the dorsal root ganglion unlike wild-type or Tg(TTR-V30M)15Imeg mice
• penetrance of thranthyretin increases with age
• mice exhibit transthyretin depositions in the sciatic nerve unlike wild-type or Tg(TTR-V30M)15Imeg mice
• at 24 months, mice exhibit collagen pockets indicating neurodegeneration unlike in Tg(TTR-V30M)15Imeg mice

digestive/alimentary system
• from 1 to 24 months of age, mice exhibit transthyretin depositions in the gastrointestinal tract unlike in wild-type mice
• mice exhibit a 2- to 3-fold higher penetrance of transthyretin deposition compared with Tg(TTR-V30M)15Imeg mice
• at 6 months, mice exhibit amyloid depositions in the stomach unlike wild-type mice
• a higher number of older mice exhibit amyloid depositions in the stomach

immune system
• in sciatic nerves and neurons of ganglion that exhibit transthyretin deposition
• in sciatic nerves and neurons of ganglion that exhibit transthyretin deposition

integument
• at 3 months, mice exhibit transthyretin depositions in the skin unlike wild-type or Tg(TTR-V30M)15Imeg mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyloidosis, Hereditary, Transthyretin-Related 105210 J:156658




Genotype
MGI:3613376
tg2
Allelic
Composition
Tg(TTR-V30M)15Imeg/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• amyloid deposition starts in the gastrointestinal tract, cardiovascular system, and kidneys 6 months after birth and extends to various other organs and tissues with advancing age
• however, amyloid does not accumulate in the choroid plexus and in the peripheral and autonomic nervous systems

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyloidosis, Hereditary, Transthyretin-Related 105210 J:80880





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory