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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mybtm1.1Cgn
targeted mutation 1.1, University of Cologne
MGI:3047076
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mybtm1.1Cgn/Mybtm1.1Cgn involves: 129P2/OlaHsd * C57BL/6 MGI:3047329
ht2
 		Mybtm1.1Cgn/Myb+ involves: 129P2/OlaHsd * C57BL/6 MGI:3764008
ht3
 		Mybtm1Cgn/Mybtm1.1Cgn involves: 129P2/OlaHsd * C57BL/6 MGI:3047330
cn4
 		Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3047331


Genotype
MGI:3047329
hm1
Allelic
Composition		 Mybtm1.1Cgn/Mybtm1.1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
anemia ( J:91122 )
• embryos die with extreme anemia between E14 - E15




Genotype
MGI:3764008
ht2
Allelic
Composition		 Mybtm1.1Cgn/Myb+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:127234 )
• block at pro- to pre-B cell transition is seen in young mice
decreased mature B cell number ( J:127234 )
• reduced in spleen at younger ages
decreased B-1 B cell number ( J:127234 )
• numbers are decreased in spleen and peritoneal cavity at 10-16 weeks of age
decreased pre-B cell number ( J:127234 )
• numbers are reduced in bone marrow and persists over time

immune system
arrested B cell differentiation ( J:127234 )
• block at pro- to pre-B cell transition is seen in young mice
decreased mature B cell number ( J:127234 )
• reduced in spleen at younger ages
decreased B-1 B cell number ( J:127234 )
• numbers are decreased in spleen and peritoneal cavity at 10-16 weeks of age
decreased pre-B cell number ( J:127234 )
• numbers are reduced in bone marrow and persists over time




Genotype
MGI:3047330
ht3
Allelic
Composition		 Mybtm1Cgn/Mybtm1.1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91122 )
• compound heterozygotes are healthy and fertile




Genotype
MGI:3047331
cn4
Allelic
Composition		 Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

immune system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

endocrine/exocrine glands
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory