Phenotypes associated with this allele

• Allele Symbol: Fxr1^tm1.2Dln
• Allele Name: targeted mutation 1.2, David L Nelson
• Allele ID: MGI:3046849
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fxr1^tm1.2Dln/Fxr1^tm1.2Dln	involves: 129P2/OlaHsd * C57BL/6	MGI:3046933

Genotype
MGI:3046933

hm1

• Allelic Composition: Fxr1^tm1.2Dln/Fxr1^tm1.2Dln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91191 )

• mutant pups die within a few hours of birth with many of the internal organs (heart, lung, brain) appearing paler than normal however hematocrit is normal

integument

abnormal skin vasculature morphology ( J:91191 )

• many large vessels clearly visible under the skin in wild-type mice can not be seen in mutants

cardiovascular system

abnormal skin vasculature morphology ( J:91191 )

• many large vessels clearly visible under the skin in wild-type mice can not be seen in mutants

abnormal myocardial fiber morphology ( J:91191 )

• cardiac muscle cells are more transparent with a reduced cytoplasmic volume and more nuclei present compared to wild-type littermates

muscle

abnormal myocardial fiber morphology ( J:91191 )

• cardiac muscle cells are more transparent with a reduced cytoplasmic volume and more nuclei present compared to wild-type littermates

abnormal muscle development ( J:91191 )

• the limb musculature is less well developed