All Phenotypes Otx2<tm7Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm7Sia
targeted mutation 7, Shinichi Aizawa
MGI:3046841

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm7Sia/Otx2^tm7Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3056055
ht2	Otx2^tm2.1Imat/Otx2^tm7Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3718488
cn3	Otx2^tm7Sia/Otx2⁺ Tg(Lefty2-cre)21bHmd/?	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3718487
cx4	Emx2^tm1Sia/Emx2^tm1Sia Otx2^tm7Sia/Otx2^tm7Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3056075

Allelic Composition	Otx2^tm7Sia/Otx2^tm7Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm7Sia mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:91012 )

N	• the epiblast develops normally • axis rotation occurs normally

nervous system

nervous system phenotype ( J:91012 )

N	• forebrain and midbrain develop normally

Allelic Composition	Otx2^tm2.1Imat/Otx2^tm7Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm2.1Imat mutation (0 available); any Otx2 mutation (50 available)
Otx2^tm7Sia mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:91012 )

N	• axis rotation occurs normally

nervous system

abnormal forebrain development ( J:91012 )

• at E12.5, forebrain defects range from mild to severe

absent midbrain ( J:91012 )

• at E12.5, in severe cases the midbrain is absent

absent forebrain ( J:91012 )

• in some cases the forebrain is absent

Allelic Composition	Otx2^tm7Sia/Otx2⁺ Tg(Lefty2-cre)21bHmd/?
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm7Sia mutation (1 available); any Otx2 mutation (50 available)
Tg(Lefty2-cre)21bHmd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:91012 )

N	• axis rotation occurs normally

Allelic Composition	Emx2^tm1Sia/Emx2^tm1Sia Otx2^tm7Sia/Otx2^tm7Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2^tm1Sia mutation (1 available); any Emx2 mutation (23 available)
Otx2^tm7Sia mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent diencephalon ( J:91012 )

• the diencephalon is lost

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