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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm6Sia
targeted mutation 6, Shinichi Aizawa
MGI:3046840
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm6Sia/Otx2tm6Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3046978
ht2
 		Otx2tm1Sia/Otx2tm6Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3046979


Genotype
MGI:3046978
hm1
Allelic
Composition		 Otx2tm6Sia/Otx2tm6Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm6Sia mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:91011 )
N
• forebrain and midbrain development appear normal




Genotype
MGI:3046979
ht2
Allelic
Composition		 Otx2tm1Sia/Otx2tm6Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm1Sia mutation (1 available); any Otx2 mutation (50 available)
Otx2tm6Sia mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:91011 )
• midbrain and forebrain development is impaired
• defects are similar but milder compared to those in Otx2tm1Sia and Otx2tm5Sia compound heterozygous mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory