• moderately accelerated mortality among females only after 56 weeks of age

• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls

• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age

• females were slower at spatial memory acquisition

• males were quicker to begin exploration in open field tests

• overall locomotor activity was increased in males

• no signs of neuritic plaque or neurofibrillar tangle formation

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form