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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apptm1Ini
targeted mutation 1, Ikuo Nishimoto
MGI:3044176
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Apptm1Ini/App+ involves: C57BL/6 * CBA * CD-1 MGI:3044184


Genotype
MGI:3044184
ht1
Allelic
Composition
Apptm1Ini/App+
Genetic
Background
involves: C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Ini mutation (0 available); any App mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• moderately accelerated mortality among females only after 56 weeks of age (J:90296)
• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls (J:90296)
• moderately accelerated mortality among females only after 56 weeks of age (J:90296)
• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls (J:90296)

behavior/neurological
• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age (J:90296)
• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age (J:90296)
• females were slower at spatial memory acquisition (J:90296)
• females were slower at spatial memory acquisition (J:90296)
• males were quicker to begin exploration in open field tests (J:90296)
• males were quicker to begin exploration in open field tests (J:90296)
• overall locomotor activity was increased in males (J:90296)
• overall locomotor activity was increased in males (J:90296)

nervous system
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form (J:90296)
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form (J:90296)
• no signs of neuritic plaque or neurofibrillar tangle formation (J:90296)
• no signs of neuritic plaque or neurofibrillar tangle formation (J:90296)

homeostasis/metabolism
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form (J:90296)
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form (J:90296)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:90296





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory