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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Amacrtm1Jkh
targeted mutation 1, J Kalervo Hiltunen
MGI:3044171
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Amacrtm1Jkh/Amacrtm1Jkh involves: 129S1/Sv * 129X1/SvJ MGI:3044685


Genotype
MGI:3044685
hm1
Allelic
Composition
Amacrtm1Jkh/Amacrtm1Jkh
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 1 in 7 homozygous mice die after 9 days on a phytol supplemented diet (J:90370)
• 1 in 7 homozygous mice die after 9 days on a phytol supplemented diet (J:90370)

adipose tissue
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet (J:90370)
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet (J:90370)

growth/size/body
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet (J:90370)
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice weigh 10% less than wild-type mice while no weight difference is detected on a normal chow diet (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice weigh 10% less than wild-type mice while no weight difference is detected on a normal chow diet (J:90370)

homeostasis/metabolism
• cholesterol concentrations are about 50% lower on either a normal chow diet or a phytol supplemented diet in homozygous mice compared to wild-type mice (J:90370)
• cholesterol concentrations are about 50% lower on either a normal chow diet or a phytol supplemented diet in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet serum alkaline phosphatase levels areincreased 175% in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet serum alkaline phosphatase levels areincreased 175% in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice had decreased palmitic, oleic, and stearic acid concentrations (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice had decreased palmitic, oleic, and stearic acid concentrations (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice had increased phytanic and pristanic acid concentrations (J:90370)
• after 6 weeks on a phytol supplemented diet homozygous mice had increased phytanic and pristanic acid concentrations (J:90370)
• after 6 weeks on a phytol supplemented diet triacylglycerols are reduced 52% in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet triacylglycerols are reduced 52% in homozygous mice compared to wild-type mice (J:90370)

liver/biliary system
• after 6 weeks on a phytol supplemented diet liver size increases to a great extent in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet liver size increases to a great extent in homozygous mice compared to wild-type mice (J:90370)
• after 6 weeks on a phytol supplemented diet livers of homozygous mice display accumulation of lymphocytes and Kupffer's cells, multivacuolar degeneration, and coagulation necrosis (J:90370)
• proliferation of enlarged and unevenly shaped smooth endoplasmic reticulum and peroxisomes is also seen (J:90370)
• after 6 weeks on a phytol supplemented diet livers of homozygous mice display accumulation of lymphocytes and Kupffer's cells, multivacuolar degeneration, and coagulation necrosis (J:90370)
• proliferation of enlarged and unevenly shaped smooth endoplasmic reticulum and peroxisomes is also seen (J:90370)
• the concentration of C24 bile acid species is reduced and the concentration of C27 bile acid precursors is increased 100 - 200 times (J:90370)
• the concentration of C24 bile acid species is reduced and the concentration of C27 bile acid precursors is increased 100 - 200 times (J:90370)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Methylacyl-Coa Racemase Deficiency; AMACRD 614307 J:90370





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory