Analysis Tools
cellular
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• brown adipose tissue primary cells fail to exhibit increased oxygen consumption in response to isoproterenol treatment unlike wild-type cells
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Allele Symbol Allele Name Allele ID |
Sqstm1tm1Jmos targeted mutation 1, Jorge Moscat MGI:3043976 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• brown adipose tissue primary cells fail to exhibit increased oxygen consumption in response to isoproterenol treatment unlike wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
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• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts
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• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
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• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts
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• IL-6 production in response to PTHrP injection is reduced in mutants
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• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
|
|
• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts
|
|
• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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