Phenotypes associated with this allele

• Allele Symbol: Glra3^tm1.1Umu
• Allele Name: targeted mutation 1.1, Ulrike Muller
• Allele ID: MGI:3043776
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glra3^tm1.1Umu/Glra3^tm1.1Umu	involves: 129P2/OlaHsd	MGI:3810132
hm2	Glra3^tm1.1Umu/Glra3^tm1.1Umu	involves: 129P2/OlaHsd * C57BL/6	MGI:3043777

Genotype
MGI:3810132

hm1

• Allelic Composition: Glra3^tm1.1Umu/Glra3^tm1.1Umu
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:132622 )

• AII amacrine cells fail to exhibit glycinergic spontaneous inhibitory postsynaptic currents

• however, narrow field amacrine cells exhibit normal glycinergic spontaneous inhibitory postsynaptic currents

vision/eye

abnormal eye physiology ( J:132622 )

• following exogenous application of glycine, mice exhibit a decrease in the current in amacrine cells compared to similarly treated wild-type cells

Genotype
MGI:3043777

hm2

• Allelic Composition: Glra3^tm1.1Umu/Glra3^tm1.1Umu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal nociception after inflammation ( J:89981 )

• homozygous mice do not show a decrease in paw withdrawal latency after exposure to heat or reaction scores after mechanical stimulation indicating a lack of sensitization following intrathecal injection of prostoglandin PGE₂

• after injection of zymosan A homozygous mice initially display increased sensitivity to thermal and mechanical stimulation but recover more rapidily than wild-type mice

• basal nociception, posture, activity, gait, motor coordination, and startle response are all normal in homozygous mutants

nervous system

nervous system phenotype ( J:89981 )

N • homozygous mice do not display any gross abnormalities of the brain or spinal cord