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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-IDE)1Selk
transgene insertion 1, Dennis J Selkoe
MGI:3043428
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Camk2a-IDE)1Selk/0
Tg(PDGFB-APPSwInd)20Lms/0
involves: C57BL/6 * DBA/2 MGI:3721976
tg2
Tg(Camk2a-IDE)1Selk/0 involves: C57BL/6 MGI:3721973


Genotype
MGI:3721976
cx1
Allelic
Composition
Tg(Camk2a-IDE)1Selk/0
Tg(PDGFB-APPSwInd)20Lms/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-IDE)1Selk mutation (1 available)
Tg(PDGFB-APPSwInd)20Lms mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• attenuated premature death at 6 months relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates

nervous system
• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%
• microgliosis is reduced
• decreased relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates
• number of dystrophic neurites is reduced relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice

homeostasis/metabolism
• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%




Genotype
MGI:3721973
tg2
Allelic
Composition
Tg(Camk2a-IDE)1Selk/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-IDE)1Selk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are fertile, with no overt abnormalities





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory