About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Bglap2-cre)1Kry
transgene insertion 1, Gerard Karsenty
MGI:3041870
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB MGI:3584276
cn2
 		Ihhtm1Amc/Ihhtm2Amc
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB MGI:3584278
cn3
 		Pthlhtm1Hmk/Pthlh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N MGI:3584345
cn4
 		Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL MGI:3584347
cn5
 		Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N MGI:3584277
cn6
 		Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:3584049
cn7
 		Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:3584275


Genotype
MGI:3584276
cn1
Allelic
Composition		 Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased long bone epiphyseal plate size ( J:99641 )
• growth plate is expanded, however less than in compound heterozygous mice that contain Ihh




Genotype
MGI:3584278
cn2
Allelic
Composition		 Ihhtm1Amc/Ihhtm2Amc
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Ihhtm2Amc mutation (0 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal chondrocyte differentiation ( J:99641 )
• ectopic hypertrophic differentiation in growth plates, however do not observe elongation of the columnar region




Genotype
MGI:3584345
cn3
Allelic
Composition		 Pthlhtm1Hmk/Pthlh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased long bone epiphyseal plate size ( J:99641 )
• growth plate is shorted by about 8%




Genotype
MGI:3584347
cn4
Allelic
Composition		 Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
Tg(Col2a1-PTHLH)1Ecw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
long tibia ( J:99641 )
• increase in tibia length
abnormal long bone epiphyseal plate morphology ( J:99641 )
• exhibit ectopically differentiated chondrocytes
abnormal chondrocyte differentiation ( J:99641 )
• eutopic hypertrophic chondrocyte differentiation is stimulated

limbs/digits/tail
long tibia ( J:99641 )
• increase in tibia length




Genotype
MGI:3584277
cn5
Allelic
Composition		 Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm2Amc mutation (0 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone hypertrophic chondrocyte zone ( J:99641 )
• elongation of the columnar region
abnormal chondrocyte differentiation ( J:99641 )
• ectopic hypertrophic differentiation in growth plates




Genotype
MGI:3584049
cn6
Allelic
Composition		 Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:77683 )
• develop ectopic hypertrophy in the columnar region of tibia due to premature hypertrophic differentiation
abnormal long bone hypertrophic chondrocyte zone ( J:77683 )
• periarticular chondrocyte differentiation into columnar cells is accelerated




Genotype
MGI:3584275
cn7
Allelic
Composition		 Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:99641 )
• chondrocytes prematurely differentiate into hypertrophic chondrocytes in the columnar region
increased long bone epiphyseal plate size ( J:99641 )
• growth plate expansion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory