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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTVTGFB1)46Hlm
transgene insertion 46, Harold L Moses
MGI:3040376
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Rb1tm1Fad/Rb1tm1Fad
Tg(MMTVTGFB1)46Hlm/?
involves: 129 * C57BL/6 * DBA/2 MGI:4354285
cx2
Tg(MMTVTGFA)29Rjc/0
Tg(MMTVTGFB1)46Hlm/0
involves: C57BL/6 * DBA/2 MGI:3800247
tg3
Tg(MMTVTGFB1)46Hlm/0 involves: C57BL/6 * DBA/2 MGI:3800230


Genotype
MGI:4354285
cx1
Allelic
Composition
Rb1tm1Fad/Rb1tm1Fad
Tg(MMTVTGFB1)46Hlm/?
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Fad mutation (1 available); any Rb1 mutation (84 available)
Tg(MMTVTGFB1)46Hlm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mammary glands have hyperplastic growth throughout development
• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct
• this genotype demonstrates that mammary hyperplasia associated with Rb1tm1Fad homozygotes still occurs in the presence of high levels of TGF-beta1

integument
• mammary glands have hyperplastic growth throughout development
• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct
• this genotype demonstrates that mammary hyperplasia associated with Rb1tm1Fad homozygotes still occurs in the presence of high levels of TGF-beta1




Genotype
MGI:3800247
cx2
Allelic
Composition
Tg(MMTVTGFA)29Rjc/0
Tg(MMTVTGFB1)46Hlm/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVTGFA)29Rjc mutation (1 available)
Tg(MMTVTGFB1)46Hlm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• widely scattered hyperplastic alveolar outgrowths are present

neoplasm
N
• unlike mice overexpressing TGFA, mice do not exhibit mammary tumors

integument
• widely scattered hyperplastic alveolar outgrowths are present




Genotype
MGI:3800230
tg3
Allelic
Composition
Tg(MMTVTGFB1)46Hlm/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVTGFB1)46Hlm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• despite abnormal morphology, mice are still able to produce milk and normally nurse their young
• multiparous mice exhibit reduced ductal branching compared to wild-type mice (J:71696)
• mammary duct tree branching development is suppressed due to decreased proliferation of mammary epithelial cells (J:72128)
• at week 13, lateral branching is virtually absent (J:72128)
• during lactation ductal and alveolar epithelial cells appear more flattened and somewhat atrophic compared to in wild-type mice
• pregnant and lactating glands exhibit fewer lobules than in wild-type mice

neoplasm
N
• unlike with overexpression of TGFA, mice do not exhibit mammary tumors
• mice exhibit fewer DMBA-induced tumors than similarly treated wild-type mice

integument
• multiparous mice exhibit reduced ductal branching compared to wild-type mice (J:71696)
• mammary duct tree branching development is suppressed due to decreased proliferation of mammary epithelial cells (J:72128)
• at week 13, lateral branching is virtually absent (J:72128)
• during lactation ductal and alveolar epithelial cells appear more flattened and somewhat atrophic compared to in wild-type mice
• pregnant and lactating glands exhibit fewer lobules than in wild-type mice

homeostasis/metabolism
• mice exhibit fewer DMBA-induced tumors than similarly treated wild-type mice





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory