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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ctnnb1tm1(Nfkbia)Rsu
targeted mutation 1, Ruth Schmidt-Ullrich
MGI:3039783
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1tm1(Nfkbia)Rsu involves: 129P2/OlaHsd * C57BL/6 MGI:3706573
ht2
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3706574


Genotype
MGI:3706573
hm1
Allelic
Composition
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1tm1(Nfkbia)Rsu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1(Nfkbia)Rsu mutation (0 available); any Ctnnb1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are not viable; time of lethality is not stated (J:71744)
• homozygotes are not viable; time of lethality is not stated (J:71744)




Genotype
MGI:3706574
ht2
Allelic
Composition
Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1(Nfkbia)Rsu mutation (0 available); any Ctnnb1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mutants live less than 6 months (J:71744)
• the maximum life span is 1 year (J:71744)
• 50% of mutants live less than 6 months (J:71744)
• the maximum life span is 1 year (J:71744)
• a proportion of mutants die during embryogenesis (J:71744)
• a proportion of mutants die during embryogenesis (J:71744)

immune system
• granulocytosis (J:71744)
• granulocytosis (J:71744)
• impaired macrophage activity (J:71744)
• impaired macrophage activity (J:71744)
• Peyer's patches are reduced in size and numbers in 90% of mutants (J:71744)
• Peyer's patches are reduced in size and numbers in 90% of mutants (J:71744)
• Peyer's patches are absent in 10% of mutants (J:71744)
• Peyer's patches are absent in 10% of mutants (J:71744)
• mutants posses only small numbers of minute axilar/brachial lymph nodes (J:71744)
• mutants posses only small numbers of minute axilar/brachial lymph nodes (J:71744)
• mutants posses only small numbers of minute axilar/brachial lymph nodes (J:71744)
• mutants posses only small numbers of minute axilar/brachial lymph nodes (J:71744)
• mutants have only small numbers of superficial cervical lymph nodes (J:71744)
• mutants have only small numbers of superficial cervical lymph nodes (J:71744)
• absent draining popliteal lymph nodes (J:71744)
• absent draining popliteal lymph nodes (J:71744)
• absent peripheral lymph nodes (J:71744)
• absent peripheral lymph nodes (J:71744)
• middle ear exhibits chronic otitis media (J:71744)
• middle ear exhibits chronic otitis media (J:71744)
• after about 1 month, mutants develop conjunctivitis (J:71744)
• after about 1 month, mutants develop conjunctivitis (J:71744)
• mutants acquire severe keratoconjunctivits sicca, due to a reduced immune response, eventually resulting in blindness (J:71744)
• mutants acquire severe keratoconjunctivits sicca, due to a reduced immune response, eventually resulting in blindness (J:71744)
• mutants infected with Leishmania major develop significantly more severe lesions than wild-type; increased infection susceptibility is caused by reduced NOS2 activity in macrophages and not by type I T-helper-cell deficiencies (J:71744)
• mutants infected with Leishmania major develop significantly more severe lesions than wild-type; increased infection susceptibility is caused by reduced NOS2 activity in macrophages and not by type I T-helper-cell deficiencies (J:71744)

vision/eye
• after about 1 month, mutants develop conjunctivitis (J:71744)
• after about 1 month, mutants develop conjunctivitis (J:71744)
• mutants acquire severe keratoconjunctivits sicca, due to a reduced immune response, eventually resulting in blindness (J:71744)
• mutants acquire severe keratoconjunctivits sicca, due to a reduced immune response, eventually resulting in blindness (J:71744)
• mutants reaching adulthood have slanted eyes (J:71744)
• mutants reaching adulthood have slanted eyes (J:71744)
• keratinization of the corneal epithelium is seen after 6 months of age (J:71744)
• keratinization of the corneal epithelium is seen after 6 months of age (J:71744)
• hyperproliferation of the corneal stroma is detected after 6 months of age (J:71744)
• hyperproliferation of the corneal stroma is detected after 6 months of age (J:71744)
• palpebral fissures are narrowed (J:71744)
• palpebral fissures are narrowed (J:71744)
• margins of the eyelids are thickened, caused by a hyperproliferative epidermis of the eyelid margin (J:71744)
• margins of the eyelids are thickened, caused by a hyperproliferative epidermis of the eyelid margin (J:71744)
• eyes open only after 2.5-3 weeks after birth (J:71744)
• however, the eye-bulb, conjunctiva, and the cornea develop normally (J:71744)
• eyes open only after 2.5-3 weeks after birth (J:71744)
• however, the eye-bulb, conjunctiva, and the cornea develop normally (J:71744)
• blindness occurs as a result of severe keratoconjunctivitis sicca (J:71744)
• blindness occurs as a result of severe keratoconjunctivitis sicca (J:71744)
• the eyes dehydrate with time due to the absence of the Meibomian glands (J:71744)
• the eyes dehydrate with time due to the absence of the Meibomian glands (J:71744)

growth/size/body
• outgrowth of incisors is delayed (J:71744)
• outgrowth of incisors is delayed (J:71744)
• outgrowth of molars is delayed (J:71744)
• outgrowth of molars is delayed (J:71744)
• abnormal incisor positioning (J:71744)
• abnormal incisor positioning (J:71744)
• incisors do not reach normal lengths in adults (J:71744)
• incisors do not reach normal lengths in adults (J:71744)
• molars do not reach normal lengths in adults (J:71744)
• molars do not reach normal lengths in adults (J:71744)
• mutants reaching adulthood are small and thin, about 50-70% of wild-type (J:71744)
• mutants reaching adulthood are small and thin, about 50-70% of wild-type (J:71744)

endocrine/exocrine glands
• atrophy of Harderian glands (J:71744)
• atrophy of Harderian glands (J:71744)
• the sweat glands are absent in the foot pads (J:71744)
• the sweat glands are absent in the foot pads (J:71744)

hearing/vestibular/ear
• hearing tests reveal deafness starting at 4-6 weeks of age (J:71744)
• hearing tests reveal deafness starting at 4-6 weeks of age (J:71744)
• middle ear exhibits chronic otitis media (J:71744)
• middle ear exhibits chronic otitis media (J:71744)

digestive/alimentary system
• lethal bleedings in the gut (J:71744)
• lethal bleedings in the gut (J:71744)
• reduction in the number of intestinal goblet cells (J:71744)
• reduction in the number of intestinal goblet cells (J:71744)
• the epithelial structure of the small intestine is loosened (J:71744)
• the epithelial structure of the small intestine is loosened (J:71744)

cardiovascular system
• lethal bleedings in the gut (J:71744)
• lethal bleedings in the gut (J:71744)
• lethal bleedings in the liver (J:71744)
• lethal bleedings in the liver (J:71744)

craniofacial
• outgrowth of incisors is delayed (J:71744)
• outgrowth of incisors is delayed (J:71744)
• outgrowth of molars is delayed (J:71744)
• outgrowth of molars is delayed (J:71744)
• abnormal incisor positioning (J:71744)
• abnormal incisor positioning (J:71744)
• incisors do not reach normal lengths in adults (J:71744)
• incisors do not reach normal lengths in adults (J:71744)
• molars do not reach normal lengths in adults (J:71744)
• molars do not reach normal lengths in adults (J:71744)

hematopoietic system
• granulocytosis (J:71744)
• granulocytosis (J:71744)
• impaired macrophage activity (J:71744)
• impaired macrophage activity (J:71744)

homeostasis/metabolism
• reduced nitric oxide production (J:71744)
• reduced nitric oxide production (J:71744)

liver/biliary system
• lethal bleedings in the liver (J:71744)
• lethal bleedings in the liver (J:71744)
• livers show an increase in embryonic (E12.5-14.5) hepatocyte apoptosis (J:71744)
• however, mutants surviving to birth and adulthood, do not show gross liver abnormalities (J:71744)
• livers show an increase in embryonic (E12.5-14.5) hepatocyte apoptosis (J:71744)
• however, mutants surviving to birth and adulthood, do not show gross liver abnormalities (J:71744)

reproductive system

skeleton

limbs/digits/tail
• in the foot pads, plicae digitalis (deeply indented transversed folds) and sweat glands are absent (J:71744)
• in the foot pads, plicae digitalis (deeply indented transversed folds) and sweat glands are absent (J:71744)

behavior/neurological
• mutants show equilibrium problems (J:71744)
• however, the inner ear structure and hair cells show no abnormalities (J:71744)
• mutants show equilibrium problems (J:71744)
• however, the inner ear structure and hair cells show no abnormalities (J:71744)

integument
• mutants exhibit an increased rate of apoptosis in many pelage follicles (J:71744)
• mutants exhibit an increased rate of apoptosis in many pelage follicles (J:71744)
• the sweat glands are absent in the foot pads (J:71744)
• the sweat glands are absent in the foot pads (J:71744)
• the only hair type found in mutants reaching adulthood is a monotrich-awl intermediate (J:71744)
• the only hair type found in mutants reaching adulthood is a monotrich-awl intermediate (J:71744)
• mutants reaching adulthood have shaggy fur (J:71744)
• mutants reaching adulthood have shaggy fur (J:71744)
• mutants reaching adulthood have no hair on the tail and behind the ears (J:71744)
• mutants reaching adulthood have no hair on the tail and behind the ears (J:71744)
• patchy alopecia in older mice (J:71744)
• patchy alopecia in older mice (J:71744)
• hair follicles develop at a slower rate (J:71744)
• hair follicles develop at a slower rate (J:71744)
• no anlagen for hair follicles is seen in the tail (J:71744)
• no anlagen for hair follicles is seen in the tail (J:71744)
• newborns produce very few hair follicles and the reduced number of hair follicles persists throughout adulthood (J:71744)
• newborns produce very few hair follicles and the reduced number of hair follicles persists throughout adulthood (J:71744)
• mutants exhibit an increased rate of apoptosis in many vibrissal follicles (J:71744)
• mutants exhibit an increased rate of apoptosis in many vibrissal follicles (J:71744)
• mutants reaching adulthood have fewer vibrissae (J:71744)
• mutants reaching adulthood have fewer vibrissae (J:71744)

cellular
• mutants exhibit an increased rate of apoptosis in many pelage follicles (J:71744)
• mutants exhibit an increased rate of apoptosis in many pelage follicles (J:71744)
• livers show an increase in embryonic (E12.5-14.5) hepatocyte apoptosis (J:71744)
• however, mutants surviving to birth and adulthood, do not show gross liver abnormalities (J:71744)
• livers show an increase in embryonic (E12.5-14.5) hepatocyte apoptosis (J:71744)
• however, mutants surviving to birth and adulthood, do not show gross liver abnormalities (J:71744)

Mouse Models of Human Disease
OMIM ID Ref(s)
Otitis Media, Susceptibility to 166760 J:71744





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory