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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Idd6C3H/HeJ
C3H/HeJ
MGI:3037121
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Idd6C3H/HeJ/Idd6C3H/HeJ NOD.C3-Idd6C3H/HeJ MGI:3804857


Genotype
MGI:3804857
hm1
Allelic
Composition		 Idd6C3H/HeJ/Idd6C3H/HeJ
Genetic
Background		 NOD.C3-Idd6C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idd6C3H/HeJ mutation (0 available); any Idd6 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK cell number ( J:137837 )
• decreased numbers of invariant natural killer (iNKT) cells in thymus, spleen and liver
• 50% decreased iNTK cell numbers compared to NOD mice
• 70%-75% decreased iNKT cell numbers compared to C3H/HeJ mice
• decreased iNKT cell proportions in pancreas infiltrates compared to NOD animals

immune system
decreased NK cell number ( J:137837 )
• decreased numbers of invariant natural killer (iNKT) cells in thymus, spleen and liver
• 50% decreased iNTK cell numbers compared to NOD mice
• 70%-75% decreased iNKT cell numbers compared to C3H/HeJ mice
• decreased iNKT cell proportions in pancreas infiltrates compared to NOD animals
decreased interferon-gamma secretion ( J:137837 )
• decreased IFN-gamma secretion after induced cytokine production (46% of IFN-gamma secretion levels in NOD mice)
decreased interleukin-4 secretion ( J:137837 )
• decreased IL-4 secretion after induced cytokine production (38% of IL-4 secretion levels in NOD mice)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory