Analysis Tools
endocrine/exocrine glands
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• levels of IgA immunoglobulin are reduced more than 5-fold
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immune system
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• plasma cells secreting IgA fail to increase their migration through a transwell in response to CCL28
• this migrational defect is observed in vivo by the deficit of IgA-secreting plasma cells found in mammary gland tissue 9 days postpartnum
• wild-type plasma cells migrate normally into the mammary gland demonstrating defects of the Ccr10 mutation are intrinsic to the plasma cell
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• there is a 70-fold reduction in the number of IgA-secreting plasma cells found in mammary gland tissues 9 days post partum compared to wild-type controls
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• levels of IgA are normal except in the milk of lactating mothers where levels are lower by more than 5-fold, and in the feces of pups with homozygote mothers where IgA levels are decreased to a similar level
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hematopoietic system
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• plasma cells secreting IgA fail to increase their migration through a transwell in response to CCL28
• this migrational defect is observed in vivo by the deficit of IgA-secreting plasma cells found in mammary gland tissue 9 days postpartnum
• wild-type plasma cells migrate normally into the mammary gland demonstrating defects of the Ccr10 mutation are intrinsic to the plasma cell
|
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• there is a 70-fold reduction in the number of IgA-secreting plasma cells found in mammary gland tissues 9 days post partum compared to wild-type controls
|
|
• levels of IgA are normal except in the milk of lactating mothers where levels are lower by more than 5-fold, and in the feces of pups with homozygote mothers where IgA levels are decreased to a similar level
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integument
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• levels of IgA immunoglobulin are reduced more than 5-fold
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cellular
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• plasma cells secreting IgA fail to increase their migration through a transwell in response to CCL28
• this migrational defect is observed in vivo by the deficit of IgA-secreting plasma cells found in mammary gland tissue 9 days postpartnum
• wild-type plasma cells migrate normally into the mammary gland demonstrating defects of the Ccr10 mutation are intrinsic to the plasma cell
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