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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hfetm3Sly
targeted mutation 3, William S Sly
MGI:3033462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hfetm3Sly/Hfetm3Sly involves: 129X1/SvJ * C57BL/6J MGI:3033469
ht2
 		Hfetm2Sly/Hfetm3Sly involves: 129X1/SvJ * C57BL/6J MGI:3033467


Genotype
MGI:3033469
hm1
Allelic
Composition		 Hfetm3Sly/Hfetm3Sly
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm3Sly mutation (0 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:88143 )
• increased hepatic iron concentrations in both males and females
• increased relative to Hfetm2Sly (H67D)
• iron has a predominantly periportal distribution

liver/biliary system
increased liver iron level ( J:88143 )
• increased hepatic iron concentrations in both males and females
• increased relative to Hfetm2Sly (H67D)
• iron has a predominantly periportal distribution

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:88143




Genotype
MGI:3033467
ht2
Allelic
Composition		 Hfetm2Sly/Hfetm3Sly
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Sly mutation (0 available); any Hfe mutation (34 available)
Hfetm3Sly mutation (0 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:88143 )
• increased hepatic iron concentrations in both males and females
• iron has a predominantly periportal distribution

liver/biliary system
increased liver iron level ( J:88143 )
• increased hepatic iron concentrations in both males and females
• iron has a predominantly periportal distribution

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:88143




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory