Phenotypes associated with this allele

• Allele Symbol: Mmp24^tm1Ski
• Allele Name: targeted mutation 1, Motoharu Seiki
• Allele ID: MGI:3028827
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp24^tm1Ski/Mmp24^tm1Ski	involves: 129P2/OlaHsd * C57BL/6J	MGI:3029892

Genotype
MGI:3029892

hm1

• Allelic Composition: Mmp24^tm1Ski/Mmp24^tm1Ski
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:87586 )

• apparently less stressed by a water T-maze test

abnormal reflex ( J:87586 )

enhanced coordination ( J:87586 )

• improved performance on rotarod test

abnormal mechanical nociception ( J:87586 )

• lack of mechanical allodynia (neuropathic pain) after ligation of sciatic nerve

abnormal pain threshold ( J:87586 )

• no change in threshold for paw withdrawal after nerve injury

nervous system

abnormal spinal cord morphology ( J:87586 )

• failure of A-beta fibers to develop after sciatic nerve injury from laminae III-VI in dorsal horn of spinal cord to lamina II where nociceptive input is usually received