Phenotypes associated with this allele

• Allele Symbol: Itgam^tm1Rws
• Allele Name: targeted mutation 1, Richard W Stokes
• Allele ID: MGI:3027319
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgam^tm1Rws/Itgam^tm1Rws	involves: 129P2/OlaHsd * C57BL/6J	MGI:3027320

Genotype
MGI:3027320

hm1

• Allelic Composition: Itgam^tm1Rws/Itgam^tm1Rws
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:65847 )

• peritoneal and alveolar macrophages show a reduction in nonopsonic binding of Mycobacterium tuberculosis; reduction in the number of macrophages able to bind bacteria and a reduction in the number of bacteria binding to the macrophage population

• opsonic binding of Mycobacterium tuberculosis by peritoneal and alveolar macrophages is also reduced compared to wild-type

• however, survival and replication of M. tuberculosis are not significantly different form wild-type

• respiratory burst activity is depleted in peritoneal macrophages

cellular

abnormal cell adhesion ( J:65847 )

• peritoneal macrophages adhere to glass at about 78% of the levels seen in wild type macrophages

• alveolar macrophages adhere to glass more efficiently than wild-type macrophages

hematopoietic system

abnormal macrophage physiology ( J:65847 )

• peritoneal and alveolar macrophages show a reduction in nonopsonic binding of Mycobacterium tuberculosis; reduction in the number of macrophages able to bind bacteria and a reduction in the number of bacteria binding to the macrophage population

• opsonic binding of Mycobacterium tuberculosis by peritoneal and alveolar macrophages is also reduced compared to wild-type

• however, survival and replication of M. tuberculosis are not significantly different form wild-type

• respiratory burst activity is depleted in peritoneal macrophages