All Phenotypes Cntnap1<tm1Pele> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cntnap1^tm1Pele
targeted mutation 1, Elior Peles
MGI:3026869

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cntnap1^tm1Pele/Cntnap1^tm1Pele	involves: ICR	MGI:4840028
hm2	Cntnap1^tm1Pele/Cntnap1^tm1Pele	Not Specified	MGI:3027010
cx3	Cntnap1^tm1Pele/Cntnap1^tm1Pele Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129P2/OlaHsd * ICR	MGI:4840027
cx4	Cntnap1^tm1Pele/Cntnap1^tm1Pele Gldn^tm1Pele/Gldn^tm1Pele	involves: ICR	MGI:4840026

Allelic Composition	Cntnap1^tm1Pele/Cntnap1^tm1Pele
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1^tm1Pele mutation (0 available); any Cntnap1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:166099 )

ataxia ( J:166099 )

• mild

nervous system

decreased nerve conduction velocity ( J:166099 )

Allelic Composition	Cntnap1^tm1Pele/Cntnap1^tm1Pele
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1^tm1Pele mutation (0 available); any Cntnap1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:87070 )

• paranodal abnormalities due to affected contactin processing

Allelic Composition	Cntnap1^tm1Pele/Cntnap1^tm1Pele Nrcam^tm1Gmt/Nrcam^tm1Gmt
Genetic Background	involves: 129P2/OlaHsd * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1^tm1Pele mutation (0 available); any Cntnap1 mutation (56 available)
Nrcam^tm1Gmt mutation (1 available); any Nrcam mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166099 )

• at P8

nervous system

abnormal axon morphology ( J:166099 )

• nodes and heminodes fail to form unlike in wild-type mice

• nodal length is increased compared to in wild-type mice

decreased nerve conduction velocity ( J:166099 )

• at P7

behavior/neurological

ataxia ( J:166099 )

• strong congenital at P4

paralysis ( J:166099 )

Allelic Composition	Cntnap1^tm1Pele/Cntnap1^tm1Pele Gldn^tm1Pele/Gldn^tm1Pele
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntnap1^tm1Pele mutation (0 available); any Cntnap1 mutation (56 available)
Gldn^tm1Pele mutation (0 available); any Gldn mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:166099 )

• at P15

nervous system

abnormal axon morphology ( J:166099 )

• nodes and heminodes fail to form unlike in wild-type mice

• nodal length is increased compared to in wild-type mice

decreased nerve conduction velocity ( J:166099 )

• at P14

behavior/neurological

ataxia ( J:166099 )

• strong congenital at P5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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