Analysis Tools
normal phenotype
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• homozygotes are born at the expected Mendelian frequency, are overtly normal, and display normal development of the lateral olfactory tract
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Allele Symbol Allele Name Allele ID |
Plxnc1tm1Alk targeted mutation 1, Alex L Kolodkin MGI:2683882 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are born at the expected Mendelian frequency, are overtly normal, and display normal development of the lateral olfactory tract
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• these neurons are distributed less coherently in the PVN relative to heterozygous controls
• more Sim1-positive neurons are in the intermediate position in mutants
• mutant OT and VP neurons are scattered along the medial-lateral axis
• in adult mutants, distribution of the midway-scattered VP and OT neurons in the PVN is less organized than in heterozygous controls
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• at P2, there is an ~3-fold increase in oxytocin-expressing (OT) neurons and an ~5-fold increase in vasopressin-expressing (VP) neurons in region between the paraventricular nucleus (PVN) and supraoptic nucleus (SON)
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• these neurons are distributed less coherently in the PVN relative to heterozygous controls
• more Sim1-positive neurons are in the intermediate position in mutants
• mutant OT and VP neurons are scattered along the medial-lateral axis
• in adult mutants, distribution of the midway-scattered VP and OT neurons in the PVN is less organized than in heterozygous controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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