Mouse Genome Informatics
hm1
    Ghrtm1Arge/Ghrtm1Arge
involves: 129S/SvEv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• weight at birth and P10 is normal, however after 2 weeks post birth, mice show growth retardation

reproductive system
• delay in sexual maturation of females

hematopoietic system
• spleen size is disproportionately reduced in size

homeostasis/metabolism
• serum IGF1 levels are undetectable

immune system
• spleen size is disproportionately reduced in size

renal/urinary system
• kidney size is disproportionately reduced in size

skeleton
• proliferative zone of chondrocytes is shorter at p22 and p30
• chondrocyte proliferation in the proliferative zone is 63% of wild-type
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes
• hypertrophic zone of chondrocytes is shorter at p22 and p30
• reduction in the height of the primary spongiosa
• average height of a hypertrophic chondrocyte is only about 70% of the controls
• delay in development of diaphyseal, but not epiphyseal, secondary ossification centers

Mouse Models of Human Disease
OMIM IDRef(s)
Laron Syndrome 262500 J:66913


Mouse Genome Informatics
cx2
    Ghrtm1Arge/Ghrtm1Arge
Igf1tm1Arge/Igf1tm1Arge

involves: 129S/SvEv * C57BL/6J * DBA * MF1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• double mutants are smaller than either single mutant mouse
• weight at birth and P10 is normal, however after 2 weeks post birth, mice are growth retarded

skeleton
• proliferative zone of chondrocytes is shorter at p22 and p30
• chondrocytes proliferation in the proliferative zone is 43% of wild-type
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes
• hypertrophic zone of chondrocytes is shorter at p22 and p30
• reduction in the height of the primary spongiosa
• average height of a hypertrophic chondrocyte is only about 70% of the controls
• delay in development of diaphyseal and epiphyseal secondary ossification centers due to hypoproliferation and reduced size of hypertrophic chondrocytes