About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ghrtm1Arge
targeted mutation 1, Argiris Efstratiadis
MGI:2681515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ghrtm1Arge/Ghrtm1Arge involves: 129S/SvEv * C57BL/6J MGI:2681520
cx2
Ghrtm1Arge/Ghrtm1Arge
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * C57BL/6J * DBA * MF1 MGI:4456249


Genotype
MGI:2681520
hm1
Allelic
Composition
Ghrtm1Arge/Ghrtm1Arge
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrtm1Arge mutation (0 available); any Ghr mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weight at birth and P10 is normal, however after 2 weeks post birth, mice show growth retardation

reproductive system
• delay in sexual maturation of females

hematopoietic system
• spleen size is disproportionately reduced in size

homeostasis/metabolism
• serum IGF1 levels are undetectable

immune system
• spleen size is disproportionately reduced in size

renal/urinary system
• kidney size is disproportionately reduced in size

skeleton
• proliferative zone of chondrocytes is shorter at p22 and p30
• chondrocyte proliferation in the proliferative zone is 63% of wild-type
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes
• hypertrophic zone of chondrocytes is shorter at p22 and p30
• reduction in the height of the primary spongiosa
• average height of a hypertrophic chondrocyte is only about 70% of the controls
• delay in development of diaphyseal, but not epiphyseal, secondary ossification centers

Mouse Models of Human Disease
OMIM ID Ref(s)
Laron Syndrome 262500 J:66913




Genotype
MGI:4456249
cx2
Allelic
Composition
Ghrtm1Arge/Ghrtm1Arge
Igf1tm1Arge/Igf1tm1Arge
Genetic
Background
involves: 129S/SvEv * C57BL/6J * DBA * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrtm1Arge mutation (0 available); any Ghr mutation (20 available)
Igf1tm1Arge mutation (0 available); any Igf1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• double mutants are smaller than either single mutant mouse
• weight at birth and P10 is normal, however after 2 weeks post birth, mice are growth retarded

skeleton
• proliferative zone of chondrocytes is shorter at p22 and p30
• chondrocytes proliferation in the proliferative zone is 43% of wild-type
• reduction in the rate of production and maturation of hypertrophic zone chondrocytes
• hypertrophic zone of chondrocytes is shorter at p22 and p30
• reduction in the height of the primary spongiosa
• average height of a hypertrophic chondrocyte is only about 70% of the controls
• delay in development of diaphyseal and epiphyseal secondary ossification centers due to hypoproliferation and reduced size of hypertrophic chondrocytes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory